Leaders PSV Eindhoven made it 15 wins from 16 matches in the Eredivisie on Saturday with a 4-0 victory at Heracles Almelo, a match that saw the home side have two players sent off.
Goals from Steven Bergwijn and Daniel Schwabb put PSV 2-0 up with just over half an hour gone.
Brandley Kuwas missed a great opportunity to pull a goal back for Heracles - and on the stroke of half-time their task became even harder as Jesper Drost was sent off after a VAR review for a foul on Pablo Rosario.
PSV added a third in the 79th minute from Denzel Dumfries' header.
In stoppage time, another VAR review, a penalty, and another Heracles red card - this time for Lennart Czyborra for handball on the goalline.
Gaston Pereiro saw his spotkick saved - only to redeem himself moments later as he headed in a fourth.